Granulocyte colony-stimulating factor preferentially stimulates proliferation of monosomy 7 cells bearing the isoform IV receptor

EM Sloand, ASM Yong… - Proceedings of the …, 2006 - National Acad Sciences
Granulocyte colony-stimulating factor (GCSF) administration has been linked to the
development of monosomy 7 … doses of GCSF on monosomy 7 cells to determine whether this …

… myeloid leukemia (AML) bearing monosomy 7 and translocation t (3; 8)(q26; q24) after 14 years of treatment with granulocyte colony-stimulating factor (G-CSF): a …

T Schroeder, B Hildebrandt, E Mayatepek… - Journal of Medical Case …, 2008 - Springer
… , granulocyte colony-stimulating factor is known to stimulate … XX karyotype in 3 cells and a
47 XX +10 karyotype in 1 cell [4, 5]. … to stimulate proliferation of monosomy 7 cells in vitro [10]. …

Granulocyte colonystimulating factor administration: adverse events

A D'Souza, I Jaiyesimi, L Trainor… - Transfusion Medicine …, 2008 - Elsevier
Granulocyte colony-stimulating factor is well tolerated and … This effect is transient and usually
reverses within 3 to 4 days … abnormalities include monosomy 7, G-CSF receptor mutations…

Prolonged granulocyte colony stimulating factor use in glycogen storage disease type 1b associated with acute myeloid leukemia and with shortened telomere length

AM Li, S Thyagu, D Maze, R Schreiber… - Pediatric Hematology …, 2018 - Taylor & Francis
… 1b are often treated with granulocyte colony stimulating factor (G-… preferential expansion of
the preexisting monosomy 7 cell … spliced G-CSF receptor isoform with demonstrable abnormal …

G-CSF and its receptor in myeloid malignancy

R Beekman, IP Touw - Blood, The Journal of the American …, 2010 - ashpublications.org
… CSF3 preferentially stimulates the clonal expansion of MDS and SAA clones with monosomy
7… carrying a targeted granulocyte colony-stimulating factor receptor mutation derived from a …

Effects of granulocyte-colony stimulating factor on chromosome aneuploidy and replication asynchrony in healthy peripheral blood stem cell donors

B Hirsch, LA Oseth, M Cain, E Trader… - Blood, The Journal …, 2011 - ashpublications.org
… Recombinant human granulocyte colony-stimulating factor (G… (No monosomy 7 cells were
detected from aplastic anemia … induce monosomy 7 or preferentially expand a monosomy 7

[HTML][HTML] A review of granulocyte colony-stimulating factor receptor signaling and regulation with implications for cancer

SD Park, AS Saunders, MA Reidy, DE Bender… - Frontiers in …, 2022 - frontiersin.org
… its receptor granulocyte colony-stimulating factor receptor (… which isoforms are expressed
in non-hematopoietic cells, … ) and class IV (differentiation defective) GCSFR isoforms are …

miR-155 Is Associated with the Leukemogenic Potential of the Class IV Granulocyte Colony-Stimulating Factor Receptor in CD34+ Progenitor Cells

HJ Zhang, L Goudeva, S Immenschuh, A Schambach… - Molecular …, 2014 - Springer
Granulocyte colony-stimulating factor (G-CSF) is a major … favors the expansion of monosomy
7 clones in response to G-… CSFRIV isoform in healthy CD34 + HSPCs. To characterize the …

The enigma of monosomy 7

T Inaba, H Honda, H Matsui - … Journal of the American Society of …, 2018 - ashpublications.org
… use of high doses of granulocyte colony-stimulating factor (G-CSF) … Preferential stimulation
of cells carrying −7 by cytokines has … receptors. However, it is not fully understood why such a …

Lessons from congenital neutropenia: 50 years of progress in understanding myelopoiesis

N Berliner - Blood, The Journal of the American Society of …, 2008 - ashpublications.org
… domain of the granulocyte colony stimulating factor receptor. … demonstrated rare cells bearing
monosomy 7, suggesting that … monosomy 7 and selective expression of the class IV isoform